In LAI dosing week 2, which schedule can be given?

In LAI dosing week 2, which schedule can be given?

• A. 25 mg LAI Q2 weeks
• B. 50 mg Q2 weeks
• C. 10 mg Q2 weeks
• D. 75 mg Q4 weeks

Answer: (A)

Long-acting injectables rely on a depot releasing the drug slowly, so achieving and then maintaining therapeutic levels during the early treatment period requires a carefully timed dosing bridge. In week 2, the goal is to keep drug exposure steady as the initial injection continues to release, without causing a large spike in concentration. A smaller dose given every two weeks provides just enough additional drug to reach the target exposure soon after initiation and then maintain it until the next scheduled dose. If you gave a much larger dose every two weeks, concentrations could rise unnecessarily high early on and increase the risk of adverse effects. A dose that’s too small might not sustain therapeutic levels, risking virologic rebound. Extending the interval to every four weeks could leave trough levels too low before the next dose is given. So, the biweekly schedule with a modest dose best preserves steady exposure during this early phase.

Long-acting injectables rely on a depot releasing the drug slowly, so achieving and then maintaining therapeutic levels during the early treatment period requires a carefully timed dosing bridge. In week 2, the goal is to keep drug exposure steady as the initial injection continues to release, without causing a large spike in concentration. A smaller dose given every two weeks provides just enough additional drug to reach the target exposure soon after initiation and then maintain it until the next scheduled dose.

If you gave a much larger dose every two weeks, concentrations could rise unnecessarily high early on and increase the risk of adverse effects. A dose that’s too small might not sustain therapeutic levels, risking virologic rebound. Extending the interval to every four weeks could leave trough levels too low before the next dose is given. So, the biweekly schedule with a modest dose best preserves steady exposure during this early phase.